Expression of Concern highlights issues with data integrity regarding serelaxin's effects on vascular cells, indicating potential inaccuracies.
EXPRESSION OF CONCERN: M. Sarwar, C. S. Samuel, R. A. Bathgate, D. R. Stewart, and R. J. Summers, “ Serelaxin-Mediated Signal Transduction in Human Vascular Cells: Bell-Shaped Concentration–Response Curves Reflect Differential Coupling to G Proteins,” British Journal of Pharmacology 172, no. 4 (2014): 1005–1019, https://doi.org/10.1111/bph.12964 This Expression of Concern is for the above article, published online on 8 October 2014 in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief, Péter Ferdinandy; the British Pharmacological Society; and John Wiley & Sons, Inc. The Expression of Concern has been agreed due to concerns raised by third parties. Specifically, the same loading control blot was found to have been presented in panels A and C of Figure 6, despite these panels representing experiments performed on different cell lines. The corresponding author acknowledged that unintentional errors may have occurred during figure preparation; however, due to the time elapsed since the article's original publication, the underlying raw data are no longer available to correct the issue. The corresponding author maintains that the results and conclusions of the article are not affected. However, as the identified concerns cannot be resolved, the journal has decided to issue an Expression of Concern to inform and alert readers.
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