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February 21, 2026Journal of Pineal Research0 citations

EXPRESSION OF CONCERN: Melatonin Protects Against the Pathological Cardiac Hypertrophy Induced by Transverse Aortic Constriction Through Activating PGC‐1β: In Vivo and In Vitro Studies

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Key Points

  • The study aimed to investigate the protective role of melatonin against cardiac hypertrophy induced by aortic constriction and the involvement of PGC-1β.
  • In vivo and in vitro studies were conducted to analyze the effects of melatonin.
  • Cardiac hypertrophy was induced using transverse aortic constriction (TAC).
  • Investigations of image data integrity and overlap were performed.
  • Concerns were raised regarding image overlap in figures presented in the original study.
  • The publisher could not validate certain data related to melatonin's effects and the implicated images.

Abstract

EXPRESSION OF CONCERN : M. Zhai, Z. Liu, B. Zhang, L. Jing, B. Li, K. Li, X. Chen, M. Zhang, B. Yu, K. Ren, Y. Yang, W. Yi, J. Yang, J. Liu, D. Yi, H. Liang, Z. Jin, R. J. Reiter, W. Duan, and S. Yu, “Melatonin Protects Against the Pathological Cardiac Hypertrophy Induced by Transverse Aortic Constriction Through Activating PGC‐1β: In Vivo and In Vitro Studies,” Journal of Pineal Research 63, no. 3 (2017): e12433, https://doi.org/10.1111/jpi.12433 . This Expression of Concern is for the above article, published online on 14 July 2017 in Wiley Online Library ( wileyonlinelibrary.com ), and has been issued by agreement between the journal Editor‐in‐Chief, Gianluca Tosini; and John Wiley & Sons Ltd. A third party raised concerns of image overlap between the 4 wk TAC image and the 8 wk Sham + Mel image in Figure 2D. An investigation by the publisher confirmed this concern and also found overlap between the Perivascular (8 wk) and Interstitial (8 wk) images in Figure 4A. The authors did not respond to an inquiry and request for original data by the publisher, and as such the data in this article related to the concerns cannot be validated. This Expression of Concern has been published in order to inform and alert readers about the concerns of image overlap in Figures 2D and 4A. The authors were informed of this Expression of Concern.

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Cite This Study

A 2026 study studied this question.

synapsesocial.com/papers/69994c6f873532290d020dcchttps://doi.org/10.1111/jpi.70119
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1EXPRESSION OF CONCERN: Melatonin protects against the pathological cardiac hypertrophy induced by transverse aortic constriction through activating <scp>PGC</scp> ‐1β: In vivo and in vitro studies2017 · 70 citations
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