In patients with severe aortic stenosis, LVEF decline to <50% (present in 21% of patients at diagnosis) began before AS became severe and accelerated after aortic valve area reached 1.2 cm2.
Cohort (n=928)
In patients with severe aortic stenosis, left ventricular ejection fraction decline begins before the stenosis becomes severe and accelerates once the aortic valve area reaches 1.2 cm.
BACKGROUND: Left ventricular ejection fraction (LVEF) is reduced in a subset of patients with severe aortic stenosis (AS). OBJECTIVES: The authors sought to determine the temporal course of reduced LVEF, its predictors, and its impact on prognosis in severe AS. METHODS: Serial echocardiograms of 928 consecutive patients with first-time diagnosis of severe AS (aortic valve area AVA ≤1 cm RESULTS: At the initial diagnosis, 196 (21%) patients had an LVEF <50% (35.1 ± 9.7%) and 732 (79%) had an LVEF ≥50% (64.2 ± 6.1%). LVEF deterioration had begun before AS became severe for those with an LVEF <50% and accelerated after AVA reached 1.2 cm CONCLUSIONS: In patients with severe AS and reduced LVEF, a decline in LVEF began before AS became severe and accelerated after AVA reached 1.2 cm
Ito et al. (Thu,) conducted a cohort in Severe aortic stenosis (n=928). Reduced LVEF (<50%) vs. LVEF ≥50% was evaluated on LVEF deterioration. In patients with severe aortic stenosis, LVEF decline to <50% (present in 21% of patients at diagnosis) began before AS became severe and accelerated after aortic valve area reached 1.2 cm2.
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