Aortic valve replacement largely reversed left ventricular dilatation and hypertrophy, and normalized ejection fraction in patients with preoperative low EF (from 38+/-8% to 60+/-16%).
Observational (n=24)
Twenty-four patients with aortic valve disease were studied before and 19+/-12 months following valve replacement with a well functioning prosthesis. Biplane left ventricular angiography and pressures were utilized to determine end-diastolic volume/m2 (EDV), end-systolic volume/m2 (ESV), ejection fraction (EF), left ventricular mass/m2 (LVM) and stroke work (SW). There were nine patients with aortic stenosis (AS), ten patients with combined stenosis and regurgitation (AS-AR), and five patients with aortic regurgitation (AR). Following surgery, patients with regurgitation preoperatively showed marked regression in EDV and ESV. All groups demonstrated regression in LVM. Fifteen patients with a normal EF preoperatively (65+/-11%) had no change after surgery; the nine patients with a low EF before surgery (38+/-8%) had a normal EF after surgery (60+/-16%). We conclude that left ventricular dilatation, hypertrophy, and reduced left ventricular pump function are largely reversible after successful aortic valve replacement.
Kennedy et al. (Thu,) conducted a observational in aortic valve disease (n=24). aortic valve replacement vs. preoperative baseline was evaluated on left ventricular function parameters (EDV, ESV, EF, LVM, SW). Aortic valve replacement largely reversed left ventricular dilatation and hypertrophy, and normalized ejection fraction in patients with preoperative low EF (from 38+/-8% to 60+/-16%).