Lidocaine and bupivacaine mixture preserves molecular stability: an in-vitro nuclear magnetic resonance study

Key Points

• This research aims to evaluate the molecular stability of a mixture of lidocaine and bupivacaine using nuclear magnetic resonance.
• In-vitro nuclear magnetic resonance was conducted to assess the molecular stability of lidocaine and bupivacaine mixtures.
• Different concentrations and ratios of the mixture were tested for stability over time.
• The mixture showed preserved molecular stability compared to individual anesthetics.
• Stability was assessed through changes in chemical shifts and relaxation times.
• Results indicate that the mixture may optimize anesthesia delivery, although clinical benefits remain uncertain.