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July 9, 2026Regional Anesthesia & Pain Medicine

Lidocaine and bupivacaine mixture preserves molecular stability: an in-vitro nuclear magnetic resonance study

Mariana Fontes Lima Neville Bernardo Oliveira Guilherme di Camillo Orfali Henrique Louzan Machado A FERREIRA Jaine Honorata Hortolan Luiz

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Key Points

This research aims to evaluate the molecular stability of a mixture of lidocaine and bupivacaine using nuclear magnetic resonance.
In-vitro nuclear magnetic resonance was conducted to assess the molecular stability of lidocaine and bupivacaine mixtures.
Different concentrations and ratios of the mixture were tested for stability over time.
The mixture showed preserved molecular stability compared to individual anesthetics.
Stability was assessed through changes in chemical shifts and relaxation times.
Results indicate that the mixture may optimize anesthesia delivery, although clinical benefits remain uncertain.

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Implication

In-vitro study investigates molecular stability of lidocaine and bupivacaine mixture, suggesting potential benefits in anesthesia practice.

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Cite This Study

Neville et al. (2026) studied this question.

synapsesocial.com/papers/6a51dd5ac18d7f28ca4fffa2 https://doi.org/10.1136/rapm-2026-108074

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Experience of using local anesthetic combinationscohort · 2021
2Comparative effectiveness of bupivacaine and lidocaine-bupivacaine mixtures in brachial plexus block: a systematic review and meta-analysis2025 · 3 citations
3Crystallization of mixtures of local anesthetics with and without select adjuvants: a semiquantitative light microscopy analysis2024 · 19 citations
4Crystallization of local anesthetic and adjuvant mixtures: a chemical analysis of the crystal precipitate composition2025 · 2 citations
5Crystal precipitates of local anaesthetic and adjuvant mixtures can be visualised and graded using ultrahigh-frequency ultrasound imagingOriginal Research · 2026

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