5,842 pubs · 241,123 cites · h-index 211
Twisted bilayer transition metal dichalcogenides, governed by a single twisted interface, offer a versatile platform for manipulating interlayer coupling and emergent optical behavior. However, despite extensive studies on single twisted interface systems, how multi‐interface twisted stacking influences nonlinear optical behavior remains unclear. Here, we address this gap by systematically investigating the nonlinear optical performance of chemical vapor deposition (CVD) grown twisted trilayer MoS 2 (TT‐MoS 2 ) with multi‐interface twisted stacking. We fabricate all nine distinct trilayer MoS 2 configurations by CVD. Raman and photoluminescence show that twisted interfaces modulate interlayer coupling, giving rise to stacking‐dependent phonon and excitonic responses. Atomic‐resolution scanning, transmission electron microscopy, and selected area electron diffraction confirm dual twisted interfaces and a supermoiré lattice. Guided by these structural insights, we examine the second harmonic generation (SHG) response across all nine trilayer configurations. Extending the coherent SH field superposition model to a trilayer system with two independent twisted interfaces, we develop a framework that describes how the dual interfaces govern the SHG intensity and polarization orientation across stacking configurations. Our findings establish TT‐MoS 2 as a versatile nonlinear platform and open new avenues for understanding and exploiting multi‐interface twisted coupling to engineer nonlinear optical responses in van der Waals materials.
Wound infections represent a major clinical concern due to their high incidence and subtle early manifestations, often resulting in prolonged healing and increased risk of complications. While wearable bioelectronics facilitate real-time diagnostics and therapeutic interventions, their widespread clinical translation remains constrained by the complexity, power demands, and high cost of current systems. Here, a wearable platform that integrates colorimetric sensors with a wireless optoelectronic microneedle patch was presented for in situ wound infection status detection and on-demand photodynamic therapy (PDT). This wireless colorimetric optoelectronic microneedle (COMN) patch enables rapid (15 min) and reliable detection of typical wound infection biomarkers with minor interference. By integrating microneedles and wireless light-emitting diodes (LEDs), this system supports concurrent delivery of photosensitizers and light into deeper wound tissues, achieving > 99.9% eradication of drug-resistant bacteria through penetration-enhanced PDT. In a murine full-thickness wound infection model, this system promptly assessed the infection status of the wound and then triggered PDT, resulting in > 3 log reduction in bacterial burden and accelerated healing, with > 80% wound closure observed by day 14. This work demonstrates a flexible and adaptive bioelectronic platform based on colorimetric analysis and optoelectronic microneedle therapy, offering an accessible strategy for precision wound care.
The telson of the mantis shrimp (Stomatopoda) withstands repeated high‐energy impacts during ritualized combat through a multiscale architecture comprising external ridges, known as carinae, and a compliant composite core. We examine the dynamic response of the biological telson using anatomically inspired two‐dimensional plane‐strain finite element models to evaluate the influence of the carinae under impact. Compared with a smoothed geometry, the ridged telson exhibits reduced shear‐strain transmission to distal regions and localized deformation associated with transient ridge flattening. The stress front also reaches the distal region later in the ridged telson, with a delay exceeding that expected from increased geometric travel distance alone. We then draw on the curved telson sidewall and oppositely curved carinae to develop bioinspired elastic structures termed Telson‐Inspired Ridged Curved Shells (TIRCS). Finite element simulations and dimensionless parametric analyses show that the interaction between the global shell curvature and the central ridge governs stiffness, peak moment, deformation mode, bidirectional snap‐through, bistability, and loading–unloading hysteresis. Experiments using vacuum‐formed specimens and a roller‐guided bending apparatus validate these trends. These findings provide a mechanics‐based foundation for architected materials leveraging geometric nonlinearities for enhanced energy dissipation, stiffness control, and multifunctionality.
The rise of intelligent systems exacerbates scenario-specific limitations in conventional rigid electronics, revealing critical compatibility gaps across emerging application fields such as wearable devices, bioelectronics, soft robotics, human-machine interfaces, etc. Adaptive conductive systems serve as critical enablers for next-generation deformable electronics through engineering deformable conductors, innovating reconfigurable circuit topologies, and implementing intelligent systems, ensuring robust electrical connectivity and dynamic compliance in variable operating environments. This review presents the research advances of adaptive conductive systems from the perspective of material innovation, circuit interconnection design, system integration, and applications. Deformable conductors consist of substrates and conductive materials with their independent intrinsic properties and synergistic effects, structural designs and fabrication methods of conductive circuits with specialized stretchable configurations, as well as intelligent systems constructed via signal processing, machine learning, and coherent integration, are systematically summarized and reviewed. Finally, current challenges and future research perspectives of adaptive conductive systems are outlined, offering deep insights into research directions and strategies.
In optoelectronic molecular systems, device performance relies critically on the efficiency of exciton transport and relaxation processes. However, conventional organic thin films typically suffer from impurity‐induced traps and nonradiative recombination, which limit efficient exciton utilization and restrict photoconversion efficiency in devices. To address this challenge, we grow layer‐controlled two‐dimensional (2D) perylene‐derivative molecular crystals with strong optical responses by van der Waals (vdW) vapor‐phase epitaxy. Such crystals exhibit near‐unity photoluminescence quantum yields, indicating highly efficient excitonic emission. The integration with transition metal dichalcogenides (TMDCs) forms hybrid organic–inorganic heterostructures where the carrier relaxation can be tunable from charge transfer to Förster resonance energy transfer (FRET). By harvesting FRET, photodetector responsivity and specific detectivity are improved by approximately three and four orders of magnitude, respectively, relative to pristine TMDCs, with reliable single‐pixel imaging capability. These 2D perylene‐derivative crystals provide an ideal materials platform for constructing hybrid vdW heterostructures for integrated on‐chip optoelectronic devices and imaging applications.
Simulation and experimental study reveals enhanced interfacial adhesion and moisture resistance in epoxy asphalt–steel slag systems, indicating a viable pathway for sustainable pavements.
Accurate prediction of nuclear magnetic resonance (NMR) shielding constants for strongly correlated systems remains challenging. In this context, we present a density matrix renormalization group self-consistent-field (DMRG-SCF) implementation for NMR shielding calculations with large active spaces. Within a gauge-including atomic orbital DMRG-SCF (GIAO–DMRG-SCF) framework, we formulate and solve the coupled-perturbed DMRG-SCF (CP-DMRG-SCF) equations using local-site effective Hamiltonians. This approach enables the direct evaluation of the wave function’s response to an external magnetic field. In the limit of small active spaces, the computed NMR shieldings are in agreement with conventional complete active space self-consistent-field (CASSCF) results, while the present approach naturally extends to larger active spaces inaccessible to standard multiconfigurational methods. Applications to a series of molecular systems, particularly strongly correlated transition metal complexes, demonstrate that the proposed implementation can be both reliable and accurate.
In this paper, we systematically investigate the near-field radiative heat transfer in a two-body system described by the Lorentz model. Under a finite temperature difference between the upper and lower plates, we explore the evolution of radiative heat transfer by tuning the longitudinal and transverse optical phonon frequencies. Our results show that the near-field radiative heat flux can exceed the blackbody radiation limit by several orders of magnitude. Both the longitudinal and transverse phonon frequencies serve as effective control knobs, enabling broadband modulation of the spectral heat transfer. Furthermore, mirror-symmetric modulation of these phonon frequencies in both plates significantly enhances the tunability of the near-field heat transfer. The findings obtained in this study provide valuable theoretical insights and a fundamental reference framework for designing actively tunable near-field thermal devices based on similar material platforms.
Experimental study demonstrates fast organic scintillation using anti-Kasha triplet excitons, indicating strong potential for low-dose medical radiography.
Materials design study demonstrates ultrafast, sensitive organic fluorescence scintillation via anti-Kasha triplet engineering, highlighting potential for low-dose medical radiography.
Cross-sectional analysis finds positive links between vitamin D and muscle health in youth, indicating grip strength poorly predicts deficiency.
Experimental study demonstrates ultrafast kinetics and high durability in Co-FeS2/C@C potassium-ion battery anodes, indicating a biomimetic path for high-power energy storage systems.
Traditional n‐i‐p perovskite solar cells (PSCs) have achieved remarkable power conversion efficiencies exceeding 26%, yet their performance and stability remain critically bottlenecked by interfacial voids and detrimental trap states at the buried interface. These structural anomalies fundamentally originate from the conventional top‐down crystallization process, where a rapidly formed top crust induces a solvent blockade effect, trapping residual solvents that subsequently evaporate to leave detrimental buried voids. Here, we overcome this kinetic limitation via a synergistic bidirectional crystallization strategy, enabled by a dual‐functional molecular linker, diethyl phosphoramidate (DAPE). By strongly anchoring to the SnO 2 substrate and chemically bridging perovskite precursors, DAPE induces a synchronous bottom‐up growth front that complements the anti‐solvent‐induced top‐down crystallization. This kinetically reconstructed process maintains open solvent‐evasion channels, effectively eliminating the solvent blockade to yield a dense, void‐free interface. Consequently, the optimized devices exhibit relaxed residual stress and minimized non‐radiative recombination, achieving a champion power conversion efficiency of 26.25% with superior operational stability. Our work underscores the vital role of regulating crystallization kinetics to eliminate physical interfacial anomalies, offering useful insights for the further development of efficient n‐i‐p PSCs.
Demonstrates high-resolution patterning in light-emitting semiconductors, indicating advances for flexible displays.
Phosphoinositide kinase containing FYVE-type zinc finger (PIKfyve) inhibitors show potential immunomodulatory activity but suffer from poor tumor targeting and formulation challenges. Herein, we screened a series of PIKfyve inhibitors and engineered selected PIKfyve inhibitor into amorphous metal-drug frameworks (aMDFs) through coordination chemistry between pyridine/imidazole moieties and tailored metal nodes verified by theoretical simulations and nuclear magnetic resonance spectroscopy. The resulting aMDFs showed enhanced stability and processability, enabling efficient encapsulation into solid lipid NPs (HF@SLN). In both orthotopic and subcutaneous murine pancreatic cancer models, HF@SLN demonstrated superior tumor growth inhibition over free PIKfyve inhibitors. HF@SLN treatment was associated with increased transcription factor EB (TFEB) expression, accompanied by enhanced cytotoxic T cell infiltration and improved antitumor immune responses in both murine and human pancreatic tumor samples. This study demonstrates the feasibility of employing carrier-free aMDFs for the formulation and delivery of pyridine- and imidazole-containing therapeutics.
Demonstrates high-contrast sensing in polymer films, suggesting new applications in technology.
Demonstrates enhanced learning outcomes in cultural communication talent cultivation, indicating improved educational frameworks.
Background SARS-CoV-2 infection is associated with neurological sequelae and may accelerate Alzheimer's disease (AD) progression through neuroinflammation and protein aggregation. However, longitudinal evidence regarding the cognitive impact of COVID-19 in patients with AD remains scarce, and this interaction requires further clarification. Objective To explore whether COVID-19 accelerates cognitive decline in patients with AD. Methods A total of 120 participants were enrolled, including 63 in the COVID-19 group and 57 in the non-COVID-19 group. The primary outcomes were disease decline and disease deterioration over three months, assessed using CDR-SB. Disease deterioration indicated clinically meaningful worsening, whereas disease decline captured subtler progression. Multivariable logistic regression adjusted for demographic, clinical, lifestyle, genetic, and disease severity factors. Overlap-Weighted Propensity Score Matching was additionally performed to reduce confounding during the 3-month follow-up. Results COVID-19 significantly increased the risk of disease decline (OR = 10.39, 95% CI:3.87 to 27.87, p < 0.001) and disease deterioration (OR = 10.37, 95% CI: 2.71 to 39.65, p = 0.001). APOE ε4 carrier status was associated with a higher risk of deterioration (OR = 1.72), while those with unknown APOE status exhibited an even greater risk (OR = 5.20, 95% CI:1.32 to 20.53, p = 0.019). Secondary analyses confirmed that COVID-19 patients experienced significantly greater increases in CDR-SB scores compared to non-COVID-19 patients. Conclusions SARS-CoV-2 infection was associated with greater short-term cognitive worsening over a three-month period in patients with AD, underscoring its potential public health relevance and the need for early surveillance to guide timely clinical management.
Shows improved radioluminescence switching in organic scintillators, suggesting better x-ray imaging capabilities.