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Latest challenges in acute ischemic stroke management involve tissue-based approaches to define a tailored ischemic penumbra to each patients. Oxygen metabolism imaging offers new perspectives to tackle these challenges. A fully automated pipeline was developed providing oxygen metabolism parameters from MRI acquisitions including advanced processing methods such as motion-correction, registration and bayesian-based deconvolution. The method was tested on an ischemia-reperfusion non-human primate model with simultaneous PET-MRI acquisitions providing gold-standard comparison of oxygen parameters. Results show strong similarities in ratio of penumbral tissues detected in the ischemic hemisphere between the two modalities and opens new perspectives of improvement in parameters definition.
Chalet et al. (2024) studied this question.
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