Why the study?
Improving the understanding of the gut microbiota's role in cardiovascular events is crucial for advancing current cardiovascular risk stratification strategies.
Is gut microbiota composition associated with subclinical atherosclerosis and lipid metabolism in adults over 45?
Population
500 Italian patients over the age of 45 from a local cohort of 1043 subjects
Comparison
Presence vs absence of subclinical atherosclerosis
Design
Substudy of a multicentre prospective open-label RCT
Key result
Gut microbiota species such as Oscillibacter sp. MSJ 31 exhibited a significant negative correlation with triglyceride levels (r = -0.16), highlighting their potential role in lipid metabolism.
Authors
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Associated with absent subclinical ASCVD; leaves open causality and therapeutic implications.
RCT (n=1,043)
Open-label
Yes
Is gut microbiota composition associated with subclinical atherosclerosis and lipid metabolism in adults over 45?
Effect estimate: r = -0.16
Specific gut microbiota profiles, notably the presence of Oscillibacter sp. and Anaerostipes hadrus, are associated with a lower likelihood of subclinical atherosclerosis and favorable triglyceride profiles.
D'aiello et al. (2025) conducted an RCT in Subclinical atherosclerosis (n=1,043). Educational mobile health intervention vs. Usual care was evaluated on Gut microbiota diversity and its correlation with subclinical atherosclerosis and lipid levels (r = -0.16). Gut microbiota species such as Oscillibacter sp. MSJ 31 exhibited a significant negative correlation with triglyceride levels (r = -0.16), highlighting their potential role in lipid metabolism.