Each 1% increase in HbA1c was independently associated with a 1.39-fold increase in the relative odds of prevalent cardiovascular disease (95% CI 1.06-1.83) among older women.
Cross-Sectional (n=1,045)
Is HbA1c associated with prevalent cardiovascular disease in the Framingham Heart Study cohort?
There is a strong, independent association between hyperglycemia, measured by HbA1c, and prevalent cardiovascular disease among older women, even in those without known diabetes.
Effect estimate: OR 1.39 (95% CI 1.06-1.83)
We studied the cross-sectional relationship between HbA1c and cardiovascular disease (CVD) in the survivors of the original cohort of the Framingham Heart Study (n = 1045). HbA1c was significantly related to prevalent CVD among women but not men. HbA1c was also related to hypertension and to the ratio of total to high-density lipoprotein cholesterol levels. In regression analyses that controlled for these and other potential risk factors, HbA1c remained significantly related to CVD among women. The relative odds of CVD increased 1.39-fold (95% confidence interval 1.06-1.83) for increases in HbA1c of 1% (e.g., for HbA1c from 5 to 6%). The relationship was not weakened when known diabetic subjects or subjects taking beta-blocker or thiazide medications were excluded from analysis. In contrast, there was no significant relationship between "casual" blood glucose and prevalent CVD. Our results reveal a strong, significant, independent association between hyperglycemia, measured by HbA1c, and CVD among older women.
Singer et al. (1992) conducted a cross-sectional in Cardiovascular disease (n=1,045). HbA1c was evaluated on Prevalent cardiovascular disease (OR 1.39, 95% CI 1.06-1.83). Each 1% increase in HbA1c was independently associated with a 1.39-fold increase in the relative odds of prevalent cardiovascular disease (95% CI 1.06-1.83) among older women.