Why the study?
Data on the prevalence of pulmonary hypertension associated with left heart disease analyzed systematically using a contemporary diagnostic framework were lacking.
Population
51 333 patients across 123 reports with HFpEF, HFrEF, MR, or AS in Austria, Germany, and Switzerland
Design
Systematic review and meta-analysis
Key result
Pulmonary hypertension associated with left heart disease has an estimated population prevalence of ~2.7% for 'at risk' and ~1.0% for 'manifest' disease in Austria, Germany, and Switzerland.
Authors
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Signals substantial PH-LHD burden; extends prevalence estimates but leaves optimal detection and management trials open.
Meta-Analysis (n=51,333)
Yes
The prevalence of pulmonary hypertension in patients with left heart disease is considerable, highlighting the need for improved detection and management strategies.
Zeder et al. (2025) conducted a meta-analysis in Left heart disease (HFpEF, HFrEF, mitral regurgitation, aortic stenosis) (n=51,333). Pulmonary hypertension associated with left heart disease has an estimated population prevalence of ~2.7% for 'at risk' and ~1.0% for 'manifest' disease in Austria, Germany, and Switzerland.