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May 1, 1972American Journal of Psychiatry335 citations

Reduced Monoamine Oxidase Activity in Blood Platelets from Bipolar Depressed Patients

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DMDennis L. MurphyRWRichard M. Weiss

Key Points

  • The study aims to determine if monoamine oxidase activity differs in bipolar depressed patients compared to nonbipolar depressed patients and controls.
  • Measured monoamine oxidase activity in blood platelets from bipolar depressed patients, nonbipolar depressed patients, and normal controls.
  • Compared the activity levels across all groups considering age and sex.
  • Monoamine oxidase activity was 45% lower in bipolar depressed patients than in nonbipolar depressed patients (p<0.05).
  • Bipolar patients showed distinct biological characteristics compared to other groups, indicating a specific subgroup in affective disorders.

Abstract

Cellular monoamine oxidase (MAO) activity measured in blood platelets is significantly (45 percent) lower in depressed patients with a history of mania (bipolar patients) than in nonbipolar depressed patients and normal controls of similar age and sex. This difference in MAO activity may be related to other biological and psychological characteristics of these patients that suggest that bipolar patients constitute a specific subgroup among patients with affective disorders.

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Cite This Study

Murphy et al. (1972) studied this question.

synapsesocial.com/papers/6a130f708793652519a6bd46https://doi.org/10.1176/ajp.128.11.1351
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