Population
Feline calicivirus (FCV) infectious cDNA clone
Design
Preclinical
Key result
Deletion or mutation of the feline calicivirus VP2 protein was lethal for the virus, indicating that VP2 is essential for the production of infectious virions.
Authors
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May inform calicivirus antiviral targets; leaves open translation beyond feline models.
The VP2 protein encoded by ORF3 is essential for the productive replication and maturation of infectious feline calicivirus virions.
Sosnovtsev et al. (2005) studied Feline calicivirus infection. Point mutations and deletions in FCV cDNA clone vs. Wild-type FCV cDNA clone / VP2 provided in trans was evaluated on Production of infectious virions. Deletion or mutation of the feline calicivirus VP2 protein was lethal for the virus, indicating that VP2 is essential for the production of infectious virions.