What does this research mean for the field?

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HDAC-targeting PROTACs offer a promising strategy to overcome the limitations of conventional HDAC inhibitors by selectively degrading specific HDAC isoforms, though significant challenges in pharmacokinetics and in vivo validation remain. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

PROTAC‐Based HDAC Degradation: A Paradigm Shift in Targeted Epigenetic Therapies

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