Cardiogenic shock in patients with acute decompensated heart failure was associated with significantly higher 4-week mortality compared to those without shock (57.8% vs. 15.2%, p < 0.001).
Observational (n=599)
Yes
ADHF in the ICU/CCU setting is a highly heterogeneous syndrome with substantial mortality, driven largely by the presence of cardiogenic shock.
Absolute Event Rate: 57.8% vs 15.2%
p-value: p=< 0.001
BACKGROUND: Little is known about the epidemiology of acute decompensated heart failure (ADHF) in patients admitted to intensive and coronary care units (ICU/CCU). Observational data may improve disease management and guide the design of clinical trials. AIMS: EFICA is an observational study of the clinical profile, management and survival of ADHF patients admitted to ICU/CCU. METHODS: The study included 599 patients admitted to 60 ICU/CCUs across France. Relevant data was recorded during hospitalisation. Survival was assessed at 4 weeks and 1 year. RESULTS: The main cause of ADHF was ischaemic heart disease (61%); 29% of patients had cardiogenic shock. Mortality was 27.4% at 4 weeks and 46.5% at 1 year, increasing to 43.2% and 62.5%, respectively, when including pre-admission deaths. Shock patients had the highest 57.8% vs. 15.2% without shock (p < 0.001) and patients with hypertension and pulmonary oedema had the lowest 4-week mortality: (7%). Pre-admission NYHA class III-IV heart failure, not initial clinical presentation, influenced 1-year mortality. CONCLUSION: ADHF is a heterogeneous syndrome. Based on initial clinical presentation, three entities with distinct features and outcome may be described: cardiogenic shock, pulmonary oedema with hypertension, and 'decompensated' chronic heart failure. This should be taken into account in future observational studies, guidelines and clinical trials.
Zannad et al. (2006) conducted an observational in Acute decompensated heart failure (ADHF) (n=599). Cardiogenic shock vs. Without cardiogenic shock was evaluated on 4-week mortality (p=< 0.001). Cardiogenic shock in patients with acute decompensated heart failure was associated with significantly higher 4-week mortality compared to those without shock (57.8% vs. 15.2%, p < 0.001).