For intermediate-to-high-risk PE with RV strain and positive troponin but stable hemodynamics, should clinicians use early catheter-directed thrombolysis or reserve it and start with anticoagulation alone?

Active since Feb 2026

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Patients affected

% risk of PE-related death, decompensation, or recurrence within 7 days

0Estimate

among intermediate-high-risk PE patients on anticoagulation alone

Resolution

No fixed date yet

Sources

How this gets settled

Resolving trial — not yet identified

Resolution

No fixed date yet

What settles itResolving-trial readout

What tips it: For haemodynamically stable but right-heart–strained PE, the balance between preventing collapse and causing major bleeding remained unresolved.

The debate

Intervene earlyvsAnticoagulate first

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Who this affects

Affected rangeEstimate

75K–120K

≈10% risk of PE-related death, decompensation, or recurrence within 7 daysEstimate

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Sources & verification

36linked & dated sources

VerifiedConfirmed against a primary source (registry API or dual-model citation gate).EstimateA computed estimate (e.g. comparable-based cost or modeled range), not a measured value.Scan-reportedReported by the scan and linked to its source — not yet independently verified.