ObjectiveAdults represent over half of incident type 1 diabetes, yet research on disease progression predominantly focuses on at-risk children. We aimed to compare autoantibody screening outcomes and type 1 diabetes progression in adults versus children.Research Design and MethodsWe studied 135,914 children (ResultsAdults were more likely than children to screen positive for a single autoantibody (4.0% vs 2.6%) but less likely for multiple autoantibodies (0.83% vs 2.8%; pConclusionAutoantibody-positive adult relatives exhibit distinct autoantibody trajectories and progression risks compared to children, suggesting the need for tailored monitoring and intervention strategies.
Templeman et al. (Tue,) studied this question.