August 11, 2025

Recurrent Acinic Cell Carcinoma of Parotid Gland Diagnosed by Fine Needle Aspiration Cytology: A Rare Case Report

Puntos clave

Recurrent acinic cell carcinoma was diagnosed with signs of aggressive features in the patient.
The case presented characteristics like increased cellularity and a high nuclear-to-cytoplasmic ratio found through FNAC.
Diagnosis confirmed through histopathology and immunohistochemistry, demonstrating the tumor's complexity.
Findings emphasize the need for careful monitoring of salivary gland tumors, especially regarding potential transformations.

Resumen

ABSTRACT Acinic cell carcinoma (ACC) is a rare malignant tumor of the head and neck region. It accounts for 12.4%–17.4% of parotid gland malignancies and approximately 3.4% of all salivary gland tumors. ACC is a low‐grade salivary gland malignancy that predominantly affects females. In some cases, ACC can undergo high‐grade transformation (HGT), resulting in more aggressive behavior. Here, we present a rare case of recurrent Acinic cell carcinoma with aggressive features and high‐grade cytomorphology—including increased cellularity, papillary and singly scattered cells, high nuclear‐to‐cytoplasmic (N:C) ratio, coarse chromatin, and single‐cell necrosis in the background—diagnosed via fine‐needle aspiration cytology (FNAC) and further confirmed by histopathology and immunohistochemistry. This case can be categorized as ACC recurrence associated with high‐grade transformation (HGT).

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Cite This Study

Khairwa et al. (Wed,) studied this question.

synapsesocial.com/papers/68a360d60a429f7973328ee7 https://doi.org/https://doi.org/10.1002/dc.25505

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