Supplemental Figure S4 from Collagen XVII Promotes Pancreatic Ductal Adenocarcinoma Tumor Growth through Regulation of PIK3R5

Puntos clave

• Collagen XVII plays a significant role in promoting tumor growth in pancreatic ductal adenocarcinoma by influencing PIK3R5 levels, enhancing cancer progression.
• Active AKT levels were notably reduced in cells lacking collagen XVII, highlighting the gene's role in cancer cell signaling and survival.
• Observational analysis of gene expression revealed notable changes in response to collagen XVII deficiency, impacting tumor behavior.
• These findings suggest that targeting collagen XVII may offer new therapeutic avenues in managing pancreatic ductal adenocarcinoma.