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January 1, 2025Open Access

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Size and softness synergy in cellular microgel uptake: a force spectroscopy study

ABAndrey BabenyshevRWTH Aachen University VSVictoria K. SwitaczRWTH Aachen University MSMarc SpehrRWTH Aachen University

Puntos clave

Ultra-soft microgels significantly improve cellular uptake efficiency compared to larger, stiffer variants.
Force spectroscopy measurements demonstrate this effect, noting that softness plays a critical role in uptake.
Microgel size alone is not a determinant for efficiency; instead, softness is the key variable affecting internalization.
This finding may influence future designs of microgels for targeted cellular delivery and therapeutic applications.

Resumen

Force spectroscopy measurements demonstrate that microgel softness, rather than size alone, determines cellular uptake efficiency, with ultra-soft microgels achieving unprecedented internalization despite micron-scale dimensions.

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Size and softness synergy in cellular microgel uptake: a force spectroscopy study | Synapse

Cite This Study

Babenyshev et al. (Wed,) studied this question.

synapsesocial.com/papers/68af6203ad7bf08b1eae2c6f https://doi.org/https://doi.org/10.1039/d5nr02681d

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