What type of study is this?

This is a Systematic Review study (also classified as: Meta-Analysis).

September 10, 2025

A systematic review and meta-analysis comparing the safety and efficacy of open oesophagectomy and hybrid minimally invasive oesophagectomy

Puntos clave

HMIE significantly reduces conduit necrosis and postoperative pneumonia compared to OE, improving patient outcomes.
Involved eight studies and over 6,000 patients, yielding critical insights into surgical techniques for oesophageal cancer.
Standard mean differences, odds ratios, and confidence intervals were utilized to assess surgical safety and efficacy.
While HMIE shows advantages, both techniques present unique risks, necessitating personalized surgical approaches.

Resumen

Introduction Surgical resection, with or without neoadjuvant therapy, remains the primary treatment for oesophageal cancer. The two main surgical approaches are open oesophagectomy (OE) and hybrid minimally invasive oesophagectomy (HMIE). However, their relative safety and efficacy remain controversial. This review aims to compare perioperative and postoperative complications between OE and HMIE in the management of oesophageal cancer. Methods Web of Science, EMBASE, PubMed, Scopus and the Cochrane Library were searched for relevant studies. Odds ratios (OR), standard mean differences (SMD) and 95% confidence intervals (CI) were used for statistical analysis. Results Eight studies involving 6,053 patients were included. HMIE was associated significantly with lower rates of conduit necrosis (risk ratio (RR)=3.54, 95% CI 1.07, 11.73; p=0.04), postoperative pneumonia (RR=1.29, 95% CI 1.05, 1.57; p=0.01) and recurrent laryngeal nerve paralysis (RR=2.51, 95% CI 1.13, 5.55; p=0.02). No significant differences were observed in Clavien–Dindo complication grades IIIa–IVb (RR=1.13, 95% CI 0.92, 1.38; p=0.24), grade V complications (RR=1.03, 95% CI 0.30, 3.51; p=0.96), bleeding, inhospital mortality, 90-day mortality, duration of surgery, hospital stay or intensive care unit stay. Although not statistically significant, OE was associated with fewer cases of anastomotic and chyle leaks. Conclusions Both OE and HMIE have distinct advantages and drawbacks. HMIE appears superior in reducing conduit necrosis, postoperative pneumonia and nerve paralysis, whereas OE has slightly lower rates of anastomotic and chyle leaks. Surgical approach should be tailored to individual patient profiles. Further studies are needed to assess long-term oncologic outcomes.

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Cite This Study

Naim et al. (Thu,) studied this question.

synapsesocial.com/papers/68c189e09b7b07f3a0613a27 https://doi.org/https://doi.org/10.1308/rcsann.2025.0066

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