In July–18 August 2025, 171 autochthonous cases with West Nile virus (WNV) infection were confirmed in Lazio, Italy: four asymptomatic blood donors, 110 with WNV fever, 57 with neuroinvasive syndrome and nine deaths. WNV lineage 2 was detected in two neuroinvasive cases. Infection with WNV was confirmed in 28 horses, five crows and a Culex pipiens pool. We present the preliminary epidemiological and phylogenetic analysis of the outbreak and the public health measures taken within a One Health approach.
Mussetto et al. (Thu,) studied this question.