A simple, precise, and accurate UV-spectrophotometric method was developed for the quantitative analysis of amlodipine (AMD) in various tablet brands available in Libya. This method was used to determine AMD at its maximum absorbance (λmax) of 238 nm in methanol. The method demonstrated linearity in the concentration range of 5-30 µg/mL for AMD drugs, with a notably high correlation coefficient (r2 = 0.9992). The detection limit and quantification limit were determined to be 1.62 and 4.88 µg/mL, respectively. The suitability of the developed method for quantitative determination of drug was proved by ICH validation. The method was effectively employed to analyze amlodipine tablets available in the Libyan market.
Faisal et al. (Tue,) studied this question.