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September 17, 2025

Evaluation of a 5-minute, clinically feasible T2 mapping sequence to detect ischemic injury to the developing femoral head: a piglet model study

Puntos clave

The 5-minute T2 mapping sequence effectively detects increased T2 values post-ischemic injury.
Twenty-four piglets were imaged using both a 5-minute and a 12-minute sequence to compare efficacy.
T2 mapping could improve detection of ischemic injuries in young children with Legg-Calvé-Perthes disease.
The technique's rapid capabilities may enable easier clinical application and monitoring of pediatric patients.

Resumen

Motivation: T2 mapping may be useful to assess the severity of ischemic injury to the femoral head in children with Legg-Calvé-Perthes disease. Goal(s): To determine whether a 5-minute, clinically available T2 mapping sequence suitable for imaging children can detect ischemic injury in a piglet model. Approach: N=24 piglets were imaged in vivo at 3T MRI before and 0 to 14 days after onset of femoral head ischemia. T2 maps acquired using 5-minute 2D MSME and 12-minute 3D SPACE sequences were compared using 3D region of interest analyses. Results: The 5-minute sequence reliably detected increased T2 values following ischemic injury to the femoral head. Impact: Ischemic injury to the femoral head can be detected using a 5-minute, clinically available T2 mapping sequence that is suitable for imaging young children. This technique may facilitate clinical translation of T2 mapping for detection and monitoring of Legg-Calvé-Perthes disease.

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