September 17, 2025

The value of combined application of 3D-ASL and DWI imaging in the differential diagnosis of renal cell carcinoma and renal pelvic carcinoma

Puntos clave

RCC has a significantly higher renal blood flow ratio and lower apparent diffusion coefficient values than RPC.
Findings suggest that combined 3D-ASL and DWI improve diagnostic accuracy for renal tumors.
The study evaluated 16 renal tumor patients, with significant implications for surgical decision-making.
3D-ASL combined with DWI provides a non-invasive diagnostic option that enhances patient safety.

Resumen

Motivation: Given that renal cell carcinoma (RCC) and renal pelvis carcinoma (RPC) with parenchymal involvement present overlapping imaging features, their accurate differentiation is essential for guiding surgical approaches. Goal(s): This study evaluates the diagnostic potential of three-dimensional arterial spin labeling (3D-ASL) and diffusion-weighted imaging (DWI) in differentiating RCC from RPC with renal parenchymal invasion. Approach: This prospective study included 16 renal tumors patients and evaluated the differences in apparent diffusion coefficient (ADC) values and renal blood flow (RBF) ratio between RCC and RPC. Results: Findings indicate that RCC has a significantly higher RBF ratio and lower ADC values. Combined use may improve diagnostic accuracy. Impact: 3D-ASL, especially when combined with DWI, represents a promising, non-invasive approach for differentiating RCC from RPC. This contrast-free approach not only enhances patient safety but also expands diagnostic options for a broader patient population, supporting more flexible clinical decision-making.

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