What type of study is this?

This is a Quantitative Study study.

September 17, 2025

Normalized cerebrovascular reactivity mapping using hypercapnia and hyperoxia challenges

Puntos clave

Normalized CBF-CVR mapping provided a more reliable measure of cerebrovascular reactivity, indicating improved accuracy in assessments.
Results showed a reduced inter-voxel coefficient of variance in normalized CBF-CVR compared to traditional BOLD-CVR techniques.
The approach utilized in this study involved both hypercapnia and hyperoxia challenges, highlighting its utility in clinical evaluations.
The reduced inter-subject variations further support the robustness of the normalized CVR method in capturing cerebrovascular functions.

Resumen

Motivation: Cerebrovascular reactivity (CVR) is an important biomarker of brain's vascular function.. BOLD-based CVR mapping techniques are susceptible to multiple BOLD confounding factors. Goal(s): To develop a normalized CVR mapping approach using BOLD MRI with both hypercapnia and hyperoxia challenges and obtain CBF-CVR, which is independent of BOLD confounding factors while maintaining its superior sensitivity. Approach: A proof-of-principle study was first performed in 7 healthy subjects, followed by a test-retest reproducibility study in 11 subjects. Results: CBF-CVR obtained from the normalized CVR approach showed smaller inter-voxel coefficient of variance (CoV) and gray matter/white matter ratio than BOLD-CVR, and also reduced inter-subject variations. Impact: The normalized CVR approach, using hypercapnia and hyperoxia challenges with BOLD acquisition to obtain CBF-CVR, can provide a more direct index of the microvascular function and would be practical and promising in clinical applications of cerebrovascular diseases.

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Cite This Study

Karimigharighi et al. (Tue,) studied this question.

synapsesocial.com/papers/68d4597031b076d99fa5c565 https://doi.org/https://doi.org/10.58530/2025/5195

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