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September 17, 2025

A Comparison of the 1-Point Dixon, Multiple Echo IDEAL, and Chemical Shift Imaging methods for Hyperpolarized 129Xe Spectroscopic Imaging

Puntos clave

Significant agreement was found between 1-Point Dixon and both ME IDEAL and CSI methods for gas-exchange metrics.
In a small cohort of eight healthy participants, histogram shape metrics showed notable differences among techniques.
The study indicates that using different hyperpolarized 129Xe imaging methods produces comparable results.
Findings suggest potential for standardizing hyperpolarized 129Xe imaging across different clinical settings.

Resumen

Motivation: Hyperpolarized 129Xe gas-exchange imaging techniques are not yet standardized across sites. Goal(s): To determine whether 1-Point Dixon, ME IDEAL, and CSI produce equivalent results. Approach: Hyperpolarized 129Xe MRI gas-exchange was measured in eight healthy participants using the 1-Point Dixon technique, and compared with either ME IDEAL or CSI, based on random assignment, in the same participant. Results: There was overall agreement between 1-Point Dixon and ME IDEAL and CSI with both global and regional measures of 129Xe gas-exchange. However, some histogram shape metrics significantly differed. Impact: These results on a small cohort of participants provide preliminary support for equivalence between 1-Point Dixon, ME IDEAL, and CSI methods in the same healthy participant. This work shows promise for the standardization of hyperpolarized 129Xe gas-exchange imaging measures.

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