What type of study is this?

This is a Experimental Study study.

September 17, 2025

Novel Dual-Tuned 31P-1H Transceiver Head Array Enables High-Resolution Whole-brain 31P MRSI for Mapping NAD+ and NADH in the Human Brain at 7T

Puntos clave

The dual-tuned head array significantly improves 31P-SNR by 5-times in peripheral areas and 2-times in deep brain regions.
Well-defined resonance signals for NAD+ and NADH were captured in four human subjects using the novel design.
The head array operates effectively without complex structures or additional components, enhancing imaging capabilities at 7T.
This innovation allows for the detailed assessment of NAD+ and NADH, informing on redox status throughout the human brain.

Resumen

Motivation: 31P MRS imaging (MRSI) at UHF offers essential phosphorous metabolites information, but requires a dedicated 1H-31P dual-frequency head coil. Goal(s): Provide advanced 31P-1H dual-frequency head array coil for B0 shimming, brain 1H MRI and high-resolution whole-brain 31P MRSI in humans at 7T. Approach: We demonstrated a novel head array operating at 1H and 31P frequencies without complex coil structures or passive/active coil components. Results: The proposed 31P-1H head array demonstrates much higher 31P-SNR (5-times in peripheral and 2-times in deep brain region) compared to the TEM volume coil, showing well defined NAD+ and NADH resonance signals in 4 subjects. Impact: The proposed 31P-1H head coil design provides excellent 1H MRI and whole-brain high-resolution 31P MRSI, making it possible to quantify and map cellular NAD+ and NADH metabolites, thereby obtaining the NAD redox status of the entire human brain at 7T.

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