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September 17, 2025

Repeatability of Ventilation Mapping from Free-Breathing 1H 3D UTE MRI: Comparison with 2D PREFUL in Healthy Volunteers

Puntos clave

Our 2-Phase 1H MRI technique shows moderate repeatability compared to both PREFUL and MoCoLoR.
Seven healthy volunteers underwent scans twice, indicating reliable measurements can be achieved.
This approach simplifies the ventilation mapping process using free-breathing UTE MRI techniques.
Providing insights into established methods, this study highlights the potential for easier ventilation imaging.

Resumen

Motivation: Hyperpolarised gas MRI, a sensitive method for imaging lung ventilation, requires specialised personnel and costly equipment. Free-breathing 1H-MRI alternatives can require complex processing, and their repeatability is not well-established. Goal(s): This study aimed to develop a simple, 2-Phase 3D 1H UTE MRI ventilation imaging approach and evaluate its repeatability compared to PREFUL and MoCoLoR. Approach: We assessed the repeatability of our 2-Phase method, PREFUL and MoCoLoR, in seven healthy volunteers scanned twice, one week apart. Results: The repeatability of each technique was moderate. Our 2-Phase technique shows comparable repeatability to PREFUL and MoCoLoR, providing a potentially simple alternative. Impact: This study reports a straightforward 2-Phase approach for mapping ventilation using free-breathing UTE 1H-MRI, while also providing valuable insights into the repeatability of existing 1H-MRI-based approaches like PREFUL and MoCoLoR.

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