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September 20, 2025

Commentary on The Hook Effect in Immunoglobulin A Measurements: A Diagnostic Challenge—A Case Series

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The hook effect in immunoglobulin A measurements can lead to inaccurate diagnostic results, posing significant challenges.
In cases discussed, the hook effect caused misleading results in immunoglobulin A tests, highlighting the need for careful interpretation.
Pathology and laboratory medicine professionals must be aware of the hook effect when diagnosing conditions using immunoglobulin A levels.
This commentary calls for increased awareness and education regarding the hook effect's implications in laboratory diagnostics.

Resumen

Journal Article Commentary on The Hook Effect in Immunoglobulin A Measurements: A Diagnostic Challenge—A Case Series Get access David N Alter David N Alter Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, United States Address correspondence to this author at: Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 1364 Clifton Road, Atlanta, GA 30322, United States. E-mail email protected. Search for other works by this author on: Oxford Academic Google Scholar The Journal of Applied Laboratory Medicine, jfaf138, https://doi.org/10.1093/jalm/jfaf138 Published: 16 September 2025 Article history Received: 18 August 2025 Accepted: 21 August 2025 Published: 16 September 2025

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