Introduction: Synovial sarcomas frequently manifest in the extremities of young people. A primary incidence in the mediastinum is exceedingly rare, with just a limited number of cases documented in global literature. We present a case of mediastinal synovial sarcoma. Case Report: This report discusses a 37-year-old male who exhibited retrosternal chest discomfort and dyspnea with exertion. Imaging revealed an anterior mediastinal mass. The pathological examination of the excised mass revealed a monophasic tumor characterized by spindle cells possessing elongated oval hyperchromatic nuclei and mild eosinophilic cytoplasm. The tumor had strong staining for TLE-1 and vimentin, validating the diagnosis of monophasic synovial sarcoma. Conclusion: The mediastinum encompasses a heterogeneous group of neoplasms, including both primary and metastatic, often posing significant diagnostic challenges. Synovial sarcoma, although uncommon in this location, should remain a key consideration in the differential diagnosis, and immunohistochemistry serves as an essential technique in this context. This case highlights the importance of recognizing this rare and aggressive tumor to guide appropriate diagnostic and optimize therapeutic decision making.
Tryambake et al. (Sat,) studied this question.