Background: Epithelial ovarian cancer remains one of the leading causes of gynecological malignancy-relatedmortality worldwide, often diagnosed at an advanced stage due to nonspecific symptoms. Biomarkers such asCancer Antigen-125 (CA-125) and hematological parameters like platelet count have been studied individually asprognostic factors. The possible correlation between elevated platelet counts and serum CA-125 levels offerspotential insight into tumor biology and patient stratification.Objectives:• To evaluate the pre-operative platelet counts in patients diagnosed with epithelial ovarian carcinoma.• To analyze the correlation between platelet counts and serum CA-125 levels.Methods: This cross-sectional observational study was conducted jointly by the Department of Obstetrics andGynaecology, Katihar Medical College and Hospital, Katihar, Bihar, and the Department of Pathology, GMCH,Purnia, Bihar, India for 12 months included patients with histopathologically confirmed epithelial ovarian cancerwho underwent surgical intervention. Pre-operative platelet counts and serum CA-125 levels were recorded.Statistical analysis was performed using SPSS version 22. Pearson’s correlation coefficient was calculated todetermine the relationship between platelet counts and CA-125 levels.Results: The study observed that a significant proportion of patients exhibited thrombocytosis pre-operatively. Apositive correlation was found between elevated platelet counts and higher serum CA-125 levels, suggesting thatthrombocytosis may reflect increased tumor burden and aggressive disease biology.Conclusion: Pre-operative thrombocytosis correlates positively with elevated CA-125 levels in epithelial ovariancancer patients. Combined evaluation of hematological and tumor markers may enhance risk stratification,prognostic evaluation, and personalized treatment planning.
Bharti et al. (Thu,) studied this question.
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