Abstract Objective: To assess the efficacy and safety of thymosin alpha 1 (Tα1) combined with sivelestat sodium and ambroxol in elderly patients with sepsis-associated acute respiratory distress syndrome (ARDS). Methods: In this single-center randomized trial, 171 elderly patients with sepsis-associated ARDS were assigned to a control group (sivelestat sodium + ambroxol, n=86) or an experimental group (same regimen + Tα1, n=85) for 7 days, both receiving high-flow nasal cannula oxygen therapy. Primary outcomes included clinical response, mortality, survival, respiratory function, and safety. Results: The experimental group showed a higher overall response rate than the control group (85.9% vs. 72.1%, PConclusions: Tα1 combined with sivelestat sodium and ambroxol enhances clinical outcomes and respiratory function, reduces mortality, and demonstrates a favorable safety profile in elderly sepsis-associated ARDS patients.
Yun et al. (Wed,) studied this question.
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