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September 24, 2025Open Access

Cerebral vein sinus thrombosis, an unusual complication of inflammatory bowel disease

Puntos clave

Cerebral venous sinus thrombosis was observed in 4 patients with inflammatory bowel disease, demonstrating the condition's severity.
The study identifies key symptoms such as confusion and seizures, emphasizing the need for prompt imaging and diagnostics to prevent misdiagnosis.
Diagnosis was confirmed through advanced imaging techniques like computed tomography and magnetic resonance venography.
Outcomes improved with therapeutic anticoagulation and management of inflammatory bowel disease, underscoring the importance of timely intervention.

Resumen

Cerebral venous sinus thrombosis (CVST) is a rare but severe complication of inflammatory bowel disease (IBD). We present 4 cases (3 cases of ulcerative colitis, 1 of Crohn’s disease) with CVST over a 10-year period (2014–2024). Symptoms included confusion, headache, seizures, and focal deficits, often initially misdiagnosed. Diagnosis required computed tomography/magnetic resonance venography. Therapeutic anticoagulation and IBD control (steroids, biologics, or surgery) led to favourable outcomes in 3 cases. One patient required thrombectomy. Thrombophilia screening revealed protein C deficiency and JAK2 mutation in 2 cases. This series highlights CVST as a critical consideration in IBD patients with neurological symptoms. Physicians should pay attention in patients who have pre-existing risk factors and in acute flare of IBD are susceptible to this unusual complication, and advocate for prompt imaging and anticoagulation.

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