Additive-free synthesis of α-keton thiol esters via oxyacylthiolation of vinyl azides with thioacids and water

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• The additive-free synthesis achieves efficient formation of α-keton thiol esters, integrating safety and simplicity.
• Direct oxyacylthiolation using vinyl azides and thioacids leads to effective bonding of C-S and C=O bonds.
• This innovative method eliminates the need for additives, offering a more sustainable and less complex synthesis route.
• The developed process relies on the unique reaction of vinyl azides with water and thioacids, yielding valuable products.

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