Gestational Trophoblastic Neoplasia (GTN) as a broad group includes partial mole and complete mole as benign lesions and Invasive Mole, Choriocarcinoma, Placental site Trophoblastic Tumour (PSTT) and Epithelioid Trophoblastic Tumour (ETT) and mixed trophoblastic tumor, as malignant lesions. Incidence of Choriocarcinoma is 1 in 20,000 to 30,000 pregnancies, of which about 50% arise from molar pregnancies, about 25% arise from previous abortions and about 25% occur following normal pregnancies. Choriocarcinomas are sensitive to Methotrexate therapy and therefore they carry better prognosis than other comparable malignancies. The tumour is aggressive in its behaviour and metastases are hyper vascular and frequent with lung being the common site.
Singh et al. (Fri,) studied this question.