Numerous single-nucleotide (SNPs) polymorphisms are linked to non-alcoholic fatty liver disease (NAFLD), including those located near lyso-phospholipase like 1 (LYPLAL1), and tribble homolog 1 (TRIB1). The genetic variations in LYPLAL1, and TRIB1 have been studied in Indian population with NAFLD in this article. Researchers investigated the association between these SNPs identified previously and liver steatosis in European and American adults of South Asian origin. The various metabolic disorders and insulin resistance are linked to type 2 diabetes and NAFLD may predispose to it. Despite the correcting of environmental factors, there is wide inter-individual variation in the occurrence of NAFLD and the progression to NASH, and the prime explanation lies in hereditary factors. 301 Indian adults underwent ultrasound (USG) during an in-person study visit with overweight or obesity (n = 184 male; n = 117 female). In this study, 155 participants had NAFLD, of which 58.7% were male and 37.41% were female. The association between sex and body mass index (BMI) was found to be moderate (P 0.08). According to the results of the study, an increase of 5 kg/m2 in BMI was associated with a 3.36 (95% CI, 1.90, 5.71) OR for males, and in women, approximately 1.92 (95% CI, 1.40, 2.64) OR was estimated. Adjusted models showed a statistically significant association of TRIB1 with hepatic steatosis (P < 0.02).
Sharma et al. (Tue,) studied this question.