Abstract Background: Microalbuminuria is a risk factor for renal failure, cardiovascular diseases, and mortality in individuals with lifestyle-related diseases. Reports on the urine protein-to-creatinine ratio (uPCR) corresponding to a urine albumin-to-creatinine ratio (uACR) of 30 mg/gCr in spot urine have been inconsistent. Because both uACR and uPCR are influenced by muscle mass, this study aimed to determine whether 24-hour proteinuria can predict 24-hour albuminuria ≥30 mg using 24-hour urine collections. Methods: Japanese outpatients with lifestyle-related diseases (hypertension, diabetes, dyslipidemia, or hyperuricemia) who had uPCR 2 were included. Patients with urine collection times within 1440 ± 144 min were analyzed. Twenty-four-hour albuminuria, proteinuria, and urinary salt excretion were calculated as: total urine values × 1440 (min)/actual collection time (min). The association between log-transformed 24-hour albuminuria and proteinuria was examined using a four-knot linear spline. ROC curve analysis determined cut-off values: CO(D), the shortest distance from (0, 1), and CO(YI), the maximum of (sensitivity + specificity – 1). Logistic regression identified predictors of 24-hour albuminuria ≥30 mg. Results: Median 24-hour albuminuria increased with higher 24-hour proteinuria in G1–4 (Adjusted R2 = 0.939, p Conclusions: Prediction of 24-hour albuminuria ≥30 mg from 24-hour proteinuria was feasible. The cut-off values of 24-hour proteinuria for detecting 24-hour albuminuria ≥30 mg in Japanese outpatients with lifestyle-related diseases were 47 mg/day (COD) and 52 mg/day (COYI) in G1–3a, and 65 mg/day (COD, COYI) in G3b–4. Trial registration: Prospectively registered.
Ogi et al. (Tue,) studied this question.
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