What type of study is this?

This is a Quantitative Study study.

October 2, 2025Open Access

Mechanisms of neuroendocrine differentiation in castration-resistant prostate cancer and advances in the treatment of neuroendocrine prostate cancer

BSBo ShaoTianjin Medical University General Hospital YZYu ZengJohns Hopkins University – Nanjing University Center for Chinese and American Studies

Puntos clave

Castration-resistant prostate cancer often progresses to neuroendocrine prostate cancer, complicating treatment.
Androgen deprivation therapy is standard but many patients develop resistance, highlighting the role of cancer stem cells.
Elucidating mechanisms behind this transition could reveal new therapeutic targets for neuroendocrine prostate cancer.
Understanding neuroendocrine differentiation may enhance treatment strategies for advanced prostate cancer.

Resumen

Aims Prostate cancer (PC) is a common male malignancy. Although androgen deprivation therapy (ADT) is standard for advanced PC, many patients develop castration-resistant PC (CRPC), and some progress to neuroendocrine PC (NEPC). This study aims to clarify mechanisms of this transition, especially the role of cancer stem cells (CSCs), and explore therapeutic targets.

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