Supplementary Figure S7 from Molecular Characterization of Residual Muscle-Invasive Bladder Cancer Identifies a Scar-Like Transcriptomic Profile with Favorable Prognosis after Neoadjuvant Therapy | Synapse
October 3, 2025Open Access
Supplementary Figure S7 from Molecular Characterization of Residual Muscle-Invasive Bladder Cancer Identifies a Scar-Like Transcriptomic Profile with Favorable Prognosis after Neoadjuvant Therapy
Puntos clave
A distinct scar-like transcriptomic profile is associated with favorable prognosis in bladder cancer after neoadjuvant therapy.
The study found significant variations in tumor purity scores across different bladder cancer subtypes, especially between LumP and Scar-like profiles.
Analysis involved evaluating the ABACUS cohort to categorize tumors into multiple subtypes based on transcriptomic characteristics.
Identifying these profiles may provide insights into treatment outcomes and guide therapeutic strategies in bladder cancer.
Resumen
Figure S7. ESTIMATE tumor purity scores for the ABACUS cohort, stratified by LumP, LumNS, LumU, Basal-Sq, NE-like, and Stroma-rich vs Scar-like and the former tumor bed.