Homeostatic Effect of Phoenix Dactylifera on Alloxan-Induced Diabetes and Aluminium-Induced Neurotoxicity in Male Wistar Rats

Introduction: This study assessed homeostatic effect of Phoenix dactylifera on alloxan-induced diabetes and aluminium-induced neurotoxicity in male wistar rats divided into 5 groups of 5 rats each. Methods: Group A; control, Group B; diabetic group, Group C; AlCl3, Group D Alloxan+ P. dactylifera, Group E; AlCl3 + P. dactylifera (0.5ml each). Diabetes was experimentally induced in groups B-D. The animals were left to acclimatize for 2 weeks and treatments were dissolved in distilled water and given orally for 2 weeks (4weeks). Blood sample was collected via ocular puncture for analysis of fasting blood glucose level. At the end of 4 weeks, the animals were sacrificed and blood samples taken for estimation of oxidative stress markers. Blood and brain samples were collected for neuromuscular function markers. Results: The results were statistically significant at 95% confidence interval. The results obtained when compared to control from showed group D and E exhibited decrease levels of lipid peroxidation (MDA), increased levels of antioxidant enzymes (SOD, CAT, GPx and GSH). There was also decrease BGL2, indicating positive glycemic control. When compared to the diabetic group, the treatment group showed a significant reduction in MDA levels and significant increase in the levels of GSH, CAT, SOD, and GPX. It also showed significant decrease in CKMM levels (less muscle activity and damage), and increase in AChE indicating nerve activity and stress was observed in control group too. Significant reduction in FBGL2 were shown. There was no significant difference in FBG1 levels. Conclusion: P. dactylifera aqueous extract exhibits potential antidiabetic and antioxidant effect in Alloxan-induced diabetic and aluminium-induced toxicity in male wistar rats. Keywords: Phoenix dactylifera; Neurologic; Diabetes; Phytochemical; Therapy