September 11, 2024

Sacubitril/valsartan alleviates myocardial infarction-induced inflammation in mice by promoting M2 macrophage polarisation via regulation of PI3K/Akt pathway

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Resumen

Macrophage polarisation-mediated inflammation plays a critical role in ventricular remodelling after myocardial infarction (MI). Sacubitril/Valsartan (Sac/Val) is an angiotensin receptor-neprilysin inhibitor that has shown beneficial effects on MI and heart failure. This study aims to further explore the mechanisms by which Sac/Val exerts its protective effects against MI.

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Jin et al. (Wed,) studied this question.

synapsesocial.com/papers/68e58cbfb6db6435875285e2 https://doi.org/https://doi.org/10.1080/00015385.2024.2400401

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