September 9, 2024Open Access

The vicious cycle of frailty and pain: a two-sided causal relationship revealed

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Resumen

The decline in physiological functions in the older people is frequently accompanied with pain and frailty, yet the causal connection between frailty and pain remains uncertain. In this study, we utilized a two-sample Mendelian randomization (MR) approach to investigate the potential causal association between frailty and pain.

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Cite This Study

Zhong et al. (Mon,) studied this question.

synapsesocial.com/papers/68e58ff2b6db64358752b7e5 https://doi.org/https://doi.org/10.3389/fmed.2024.1396328

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1Cross-national disparities in sex differences in life expectancy with and without frailty2013 · 113 citations
2Multi-OMICS analyses of frailty and chronic widespread musculoskeletal pain suggest involvement of shared neurological pathways2018 · 59 citations
3The silent epidemic of chronic pain in older adults2019 · 423 citations
4A framework for the investigation of pleiotropy in two‐sample summary data Mendelian randomization2017 · 2,043 citations
5Frailty for Perioperative Clinicians: A Narrative Review2020 · 295 citations

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