Supplementary Figures S1-S9 from Disruption of KLHL6 Fuels Oncogenic Antigen Receptor Signaling in B-Cell Lymphoma

Figure S1 shows KLHL6 expression and its molecular correlates in reactive lymphoid and DLBCL tissues. Figure S2 shows recurrent KLHL6 mutations and their subcellular localization. Figure S3 shows data from affinity-purification mass-spectrometry (AP-MS) interactome analysis of Strep-tagged wild-type KLHL6 in the expansion cell line panel. Figure S4 shows data related to proximity-labeling interactome analysis of KLHL6. Figure S5 shows KLHL6 interactome upon BCR stimulation and the impact of recurrent mutations on BCR levels. Figure S6 shows the impact of KLHL6 constructs on the surface levels expression of the BCR components. Figure S7 shows the impact of KLHL6 constructs on the BCR signaling. Figure S8 shows immunofluorescent analysis and quantification of CD79B staining intensity. Figure S9 shows BANK1 expression in DLBCL.