Paracentral acute middle maculopathy and risk of cardiovascular disease, stroke, and death: a longitudinal study

PurposeTo evaluate the risk of acute cardiovascular events (CVE), including cardiovascular diseases, cerebrovascular diseases, and all-cause mortality in patients with paracentral acute middle maculopathy (PAMM).DesignRetrospective cohort study.MethodsWe studied 43 individuals with optical coherence tomography-documented PAMM attending Moorfields Eye Hospital between January 2014 and June 2021. We excluded patients with preceding (<2 years) major adverse cardiac events. We stratified patients by age (<50 and ≥50 years) and whether associated with retinal vascular diseases (RVD) or isolated (iPAMM). We assessed risk factors, clinical characteristics, and visual prognosis of the patients. CVE risk was estimated using Kaplan–Meier curves, the log-rank test, and Cox proportional hazards regression.ResultsIn young patients with iPAMM patients (n = 12), underlying predisposing factors included six (50%) sickle cell disease and five (41.6%) others, including breakthrough bleeding in pregnancy, migraine, genetic cardiomyopathy, amphetamine use; among those with PAMM + RVD (n = 12) one (9%) had a vascular disorder, and four (44.4%) oral contraceptive use. In the older group of 20 patients, 15 (75%) had at least one coronary risk factor. During a median follow-up of 14 months (range 12-54), older subjects with iPAMM had a higher risk of developing CVE than those with PAMM + RVD (P < .001). Notably, iPAMM displayed a significantly earlier peak in peri-PAMM CVE risk compared to PAMM + RVD (median: one month, range 1-40 months vs 36 months, range 12-54 months). Relative to those with PAMM + RVD, risk of CVE was significantly higher in patients with iPAMM, adjusted for age and sex (hazard ratio: 6.37, 95% confidence interval 1.68-24.14, P = .017). No young patients experienced adverse CVE. At baseline, older iPAMM patients mean best corrected visual acuity of 0.7 (0-1.8) logarithm of the minimum angle resolution, which improved significantly to 0.2 (0-1.30) logarithm of the minimum angle resolution at the latest visit (P = .033).ConclusionsYoung individuals with iPAMM have a higher prevalence of predisposing factors compared to those presenting with combined PAMM + RVD. Older patients with iPAMM had a higher risk of CVE than those with PAMM + RVD, especially in the peri-onset timeframe. This suggests the need for a prompt cardiovascular assessment to rule out systemic etiologies and optimize cardiovascular risk factors, in addition to ongoing ophthalmology input.