Age-dependent co-variation networks in myelin-related images

Myelin co-variation networks was used to investigate the myelinic alteration in brain degradation. However, a systematic investigation of age-related co-variation networks of multiple myelin-related images remains deficient. We aimed to investigate the age-related effect on myelin co-variation networks in gray matter and white matter. Our results revealed that different myelin-related indices presented different age-dependent evolution of co-variation networks. The age-dependencies of strength of co-variation and topological attributes were mostly in complex polynomial pattern. The investigation of multiple age-related myelin co-variation networks might comprehend the synchronous changes between brain regions and demonstrated its usefulness in predicting the alteration of myelinic tissue.