Feasibility of Highly-accelerated High b-value Multi-shot Diffusion Weighted Imaging by Using Parametric POCSMUSE and Kurtosis Model

High b-value DWI is promising in detection of white matter pathology and infarctions. However, the disadvantages of the acquired high b-value DWI, such as insufficient SNR and image distortions, prohibits its clinical application. Though the feasibility of computed high b-value has been estimated in prostate cancer, the parameters derived from low b-value images cannot be used for diffusion kurtosis model fitting and achieved inferior performance at high b-value. In this study, we proposed a framework based on parametric POCSMUSE and kurtosis model to generate multiple high b-value images with comparable image quality to MUSE from highly-accelerated high b-value DWI.