Intra-bin correction and inter-bin compensation of respiratory motion in free-running 5D whole-heart MRI

In this work, we develop, validate, and apply a novel reconstruction framework for intra-bin correction and inter-bin compensation of respiratory motion in cardiac and respiratory motion-resolved free-running whole heart 5D MRI. We demonstrate respiratory resolved images with reduced artifact and without compressing the underlying physiological motion providing a means to increase the acquired resolution, accelerate the acquisition, or investigate respiratory driven changes in cardiac output and blood flow, potentially leading to new MRI driven biomarkers for cardiovascular disease