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The reversible component of transverse relaxation time, R2’, enables the measurement of blood oxygenation, an important biomarker in several diseases. We propose a multi-echo HEPI technique to estimate R2’. HEPI combines GRE and SE and hence provides R2* and R2, when acquired at different echo-times. The accuracy of ME-HEPI in measuring R2’ is evaluated in a phantom in this work. The sensitivity of HEPI to different oxygenation levels, attained using respiratory challenge MRI, is studied in a healthy subject. This is also investigated using a simulation tool that simulates microvasculature and MR signal for varying oxygenation in the vessels.
Venugopal et al. (Wed,) studied this question.