Simultaneous Measurements of GABA, Glx and GSH in the Thalamus in Patients with Mild Traumatic Brain Injury: A Preliminary Study

In this study, we report the preliminary results of simultaneous measurements of GABA, Glx (glutamate + glutamine), and GSH in the thalamus using HERMES in the mTBI patients. HERMES was acquired in the thalamus for patients in acute, subacute, and chronic stages, and control subjects as reference using optimized acquisition and processing. Metabolite fitting were performed in Gannet with spectral alignment. The results demonstrate that HERMES can maintain the spectral and fitting quality in the mTBI patients versus the control subjects. Differences in the metabolite levels warrant accruing a larger number of patients for a more definite evaluation.